Seth DonougheGraduate Student
Current Position: Postdoc, University of Chicago
Seth was captivated by the complexity in biological systems when he was an undergraduate at Swarthmore College. While there, he studied dragonfly wing structure with Rachel Merz and anemone behavior with Liz Vallen.
After graduating, he worked in the lab of Steve DiNardo at the University of Pennsylvania School of Medicine, where he was given the opportunity to shift my focus to Drosophila developmental genetics. There, his research centered on how planar polarity is established in a growing fly.
As a graduate student in the the OEB program, Seth was supported by a National Science Foundation Graduate Research Fellowship. In his doctoral work, Seth explored various aspects of early insect development, with the goal of uncovering a little bit more about how different groups have evolved.
Church, S.H., de Medeiros, B.A.S., Donoughe, S.D., Marquez Reyes, N.L. and Extavour, C.G, 2021. Repeated loss of variation in insect ovary morphology highlights the role of developmental constraint in life-history evolution. Proceedings of the Royal Society – Part B.
Church, SH*, Donoughe, S*, De Medeiros, BA and Extavour, CG, 2019. Insect egg size and shape evolve with ecology but not developmental rate. Nature, 571(7763). 58. BioRxiv doi: 10.1101/471946
Church, SH*, Donoughe, S*, de Medeiros, BA and Extavour, CG, 2019. A database of egg size and shape from more than 6,700 insect species. Scientific Data, 6. BioRxiv doi: 10.1101/471953.
Donoughe, S. and Extavour, C.G. Embryonic development of the cricket Gryllus bimaculatus. Developmental Biology 411(1): 140-156 (2015).
Donoughe, S., Nakamura, T., Ewen-Campen, B., Green II, D.A., Henderson, L. and Extavour, C.G. BMP signalling is required for generation of primordial germ cells in an insect. Proceedings of the National Academy of Sciences of the USA 111(11): 4133-4138 (2014).
Ewen-Campen, B., Donoughe, S., Clarke, D.N., and Extavour, C.G. Germ cell specification requires zygotic mechanisms rather than germ plasm in a basally branching insect. Current Biology doi 10.1016/j.cub.2013.03.063, Epub 25 April (2013).
Resilin in dragonfly and damselfly wings and its implications for wing flexibility. Donoughe, S., Crall, J.D., Merz, R.A. and Combes, S.A. Journal of Morphology 272(12):1409-21 (2011).
dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis. Donoughe, S. and DiNardo, S. Development 138: 2751-9 (2011).